Leflunomide (LEF)

Drug Name
Leflunomide (LEF)

Brand Name(s)
Arava®, generics

Drug Class
Disease-Modifying Anti-Rheumatic Drug (DMARD)

Leflunomide (LEF) is a DMARD used to treat inflammatory types of arthritis, such as rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Leflunomide is thought to suppress the immune system by blocking T-cell activity. You may experience nausea or diarrhea while on leflunomide. This side effect should be transient but taking leflunomide before bed may help to mitigate the effects. 

This information was last updated in June 2024 with expert review and advice by:

Alan Low, BSc(Pharm), PharmD, ACPR, FCSHP, CCD, RPh
Clinical Professor, Faculty of Pharmaceutical Sciences, University of British Columbia
Pharmacy Lead and Primary Care Pharmacist, BioPro Biologics Pharmacy 
Care Director, MedInfuse Health

Garrett Tang, PharmD, RPh
Pharmacist Services Coordinator, MedInfuse Health

We also thank previous expert contributor:

Jason Kielly, BSc(Pharm), PharmD
Assistant Professor, School of Pharmacy, Memorial University of Newfoundland
Clinical Pharmacist, Rheumatic Health Program, Eastern Health

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