Colchicine

Colchicine is used to help treat and prevent gout attacks.

Colchicine is taken orally in pill form.

Colchicine is available in 0.6 mg tablets.

The usual dose to treat acute gout attacks is:

• 1.2 mg at the first sign of flare, then
•  0.6 mg in 1 hour
• Start preventative doses 12 hours later

The usual dose to prevent gout attacks is:

• 0.6 mg once to twice daily

For best results colchicine should be started within 24 hours of a gout attack.

If you are starting allopurinol your prescriber may recommend taking 0.6 mg once or twice daily for  3 – 6 months.

If you have poor kidney function and you will be taken colchicine for more than 10 days you may need a lower daily dose. Please discuss this with your healthcare provider.

An attack of gout is caused when the body’s immune system attacks uric acid crystals that form in the joints, tendons and surrounding tissues. Colchicine works by disrupting the ability of immune system cells to replicate. This helps to reduce inflammation and patients who take colchicine can benefit from reduced swelling and pain associated with gout attacks.

Colchicine typically begins to take effect within one hour.

Colchicine may not be appropriate if you have stomach ulcers or other serious stomach conditions. Colchicine may not be appropriate if you have abnormal blood counts or severe kidney problems. Please talk to your prescriber about this before starting colchicine. 

Colchicine has not been well studied in pregnancy. Colchicine does pass into breast milk. Colchicine is likely safe in breastfeeding/chestfeeding although human data is limited. Colchicine is considered by the American Academy of Pediatrics to be compatible with breastfeeding/chestfeeding. Before starting colchicine, tell your healthcare provider if you are pregnant or planning to become pregnant. 

Colchicine interacts with a number of other medications and grapefruit juice. Please speak with your healthcare provider about whether any of the other medications you currently take interact with colchicine.

Anyone who is hypersensitive to colchicine or has had a previous allergic reaction to colchicine should avoid the medication.

Colchicine can cause a number of stomach issues. The most common side effect of colchicine is diarrhea. At higher doses colchicine can also cause abdominal pain/cramps, nausea, and vomiting. 

Rarely, when used for long periods of time, colchicine can affect your muscles. If you experience any muscle pain or weakness while taking colchicine, let your prescriber know.

Take your colchicine as prescribed and contact your healthcare provider if you have any concerns while taking the medication.

To reduce severe stomach issues your prescriber may reduce your dose.

Drinking alcohol can contribute to gout flares. It is best to avoid alcohol if you have gout.

Blood tests may be required every 6 months while you are taking colchicine. This will help check your blood counts, kidney function and follow the activity of your gout.

Store this medication at room temperature (15 to 30 degrees Celsius) and keep it out of reach of children.