Allopurinol should not be started for the first time during an acute gout attack as it may make the attack worse.
Allopurinol has not been well studied in pregnancy. Human data suggests that risks may be low, and that allopurinol may be safe, but before starting allopurinol tell your healthcare provider if you are pregnant or planning to become pregnant.
Allopurinol does pass into breast milk. Allopurinol is likely safe in breastfeeding/chestfeeding although human data is limited. Allopurinol is considered by the American Academy of Pediatrics to be compatible with breastfeeding/chestfeeding. Breastfed/chestfed infants of lactating parents receiving allopurinol should be monitored for signs of allopurinol side effects, such as rash. Infants whose parent requires treatment with allopurinol may also require periodic blood work.
Allopurinol interacts with a number of other medications. Please speak with your healthcare provider about whether any of the other medications you currently take interact with allopurinol.
Allopurinol may cause a rash which, in rare cases, may develop into a serious skin reaction. If you experience a rash while using allopurinol, stop the medication immediately and consult your healthcare provider.
Anyone who is hypersensitive to allopurinol or has had a previous allergic reaction to allopurinol should avoid the medication.