Like all medications, taking infliximab carries some risk of side effects, which must be balanced with the potential benefits. In general, the risk of joint damage and permanent disability (resulting from arthritis) is much greater than the risks of side effects from infliximab. When monitored properly the vast majority of side effects are rare and most improve over time and are reversible.
Firstly, infliximab can increase your risk of infections.
Infliximab can in rare cases cause an allergic reaction during the infusion (flushing, itching, changes in heart rate and blood pressure, etc.). A health-care professional will monitor for this reaction during the infusion.
In rare cases, people experience headaches, nausea, abdominal pain and diarrhea with infliximab. If this becomes severe please consult your health-care provider.
Some people have developed lupus-like symptoms that disappeared after the medication was stopped. If you have chest pains that do not go away, shortness of breath or a rash on your cheeks or arms that gets worse in the sun, call your doctor right away.
There have been rare cases of disorders that affect the nervous system of people taking infliximab or other TNF-blockers. Signs that you could be experiencing a problem affecting your nervous system include: numbness or tingling, problems with your vision, weakness in your legs, and dizziness.
Infliximab very rarely can cause a drop in drop in the number of certain types of blood cells or problems with the liver.