In general, celecoxib is fairly well tolerated. More common side effects include stomach issues, such as bloating, nausea, stomach pain, heartburn and constipation. Celecoxib is generally better tolerated in terms of stomach issues compared to other NSAIDs.
Rare side effects of celecoxib include:
- allergic reactions such as skin rashes or wheezing
- headaches, dizziness or ringing in the ears (tinnitus)
- unusual bruising or bleeding
- kidney problems
- gastrointestinal problems — celecoxib can cause irritation to the stomach, causing nausea and vomiting
Celecoxib has been custom-designed to minimize the risk of stomach ulcers that is associated with other NSAIDs. It is not known if this advantage is maintained with long term celecoxib therapy and this advantage is substantially reduced for people taking low dose aspirin for cardiovascular protection.
Ulcers usually cause stomach pain, nausea and sometimes vomiting, but in some people ulcers produce no symptoms. Signs of stomach bleeding may include vomit that looks like it has “coffee grounds” in it, vomiting blood or black, tarry bowel movements. Let your health-care provider know if you:
- have any stomach pain, nausea, heartburn or indigestion
- notice any black or bloody stools,
- are vomiting blood or “coffee ground” material
- fluid retention — celecoxib can cause fluid retention with swelling of the ankles
- blood pressure — celecoxib can increase blood pressure, which should be monitored periodically, especially if you have hypertension