Like all medications, taking apremilast carries some risk of side effects, which must be balanced with the potential benefits. In general, the risk of joint damage and permanent disability (resulting from arthritis) is much greater than the risks of side effects from apremilast. When monitored properly the vast majority of side effects are rare, most improve over time and are reversible.
Apremilast can cause significant weight loss in some patients. Let your health-care provided know if you start to experience weight loss while taking the medication.
Other common side effects you may experience while taking apremilast include nausea, stomach pain and diarrhea. Patients have also reported experiencing nasal congestion and sore throat (e.g., the common cold), flu-like symptoms (body aches and pains, tiredness or fever), and headaches. Talk to your health-care provider if any of these symptoms affect you severely.