Taking abatacept can make it more difficult for your body to fight infections. Therefore, people with active infections should not take abatacept. If you have a fever, think you have an infection or have been prescribed an antibiotic, contact your healthcare provider. People who have had frequent infections in the past or a history of tuberculosis should discuss the use of abatacept with their healthcare provider. Also, contact your healthcare provider if you are having surgery as you may need to stop abatacept until you are healed and there is no sign of infection.
Abatacept has not been studied in pregnant people or lactating parents so its effect(s) on pregnant people or nursing babies are unknown. You should tell your doctor if you are pregnant or are planning to become pregnant. Because of the potential for adverse reactions in nursing infants, a decision should be made with your healthcare provider on whether or not to discontinue nursing or the medication, taking into account the importance of the drug to the lactating parent.
Anyone who has had a previous allergic reaction to abatacept should avoid the medication.
People with a history of cancer or emphysema should discuss the use of abatacept with their healthcare provider.
Before starting this medication, you will likely be tested for inactive (“latent”) tuberculosis (TB) and hepatitis B because abatacept can dampen the immune system and cause these infections to become active. If TB or hepatitis is found, it will need to be treated before you start abatacept.
Make sure that your vaccinations are up to date before starting abatacept. Your healthcare provider will likely recommend a number of vaccines (e.g., influenzae, pneumonia, RSV, shingles) to get beforehand. Because abatacept can decrease your ability to respond to vaccines, you should wait at least two to three weeks after your last vaccine before starting abatacept. If you are already on abatacept and need a vaccination, talk to your healthcare provider about vaccine spacing and whether or not you need to hold abatacept. Live vaccines are not recommended due to risk of causing infection. Before receiving any vaccinations while taking abatacept, you should speak with your healthcare provider.