Duloxetine is a first-line agent for fibromyalgia and a second-line agent for treatment of osteoarthritis (OA) of the knee that has not responded to acetaminophen or non-steroidal anti-inflammatory drugs (NSAIDs). Duloxetine works by blocking neurotransmitters (serotonin and norepinephrine) that are involved in nerve pain. Stopping this medication requires monitoring by a healthcare provider as that may cause withdrawal side effects.
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As an organization with nationwide reach, we recognize our work occurs on traditional Indigenous territories across Canada. Arthritis Society Canada’s national office is located in Toronto (Tkaronto), which is the traditional territory of many nations, including the Mississaugas of the Credit, the Anishinaabeg, the Chippewa, the Haudenosaunee, and the Wendat peoples. We also acknowledge this land is now home to many diverse First Nations, Inuit and Métis peoples. We encourage you to learn more about the nations, land, and communities in the areas where you live. Read our full statement.
